We are recruiting! Please contact Pengchun (Pengchun-Yu@omrf.org) if you are interested in the following positions.
The laboratory of Dr. Pengchun Yu in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists to investigate the metabolic regulation of vascular formation and its implications in vascular diseases.
The laboratory focuses on the interface between cellular metabolism and vascular biology. Dr. Yu has recently demonstrated that MYC/hexokinase 2 pathway-driven glucose metabolism in endothelial cells controls blood and lymphatic vessel formation dependent on fibroblast growth factor receptor (FGFR) signaling (Yu et al., Nature, 2017). Research projects of the laboratory are built upon this important finding to further study the crosstalk between metabolic programs and angiogenic signaling events and to understand the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be employed, ranging from novel genetically-modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.
OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers several critical areas such as cardiovascular disease, autoimmune disease, and cancer. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories. Moreover, postdoctoral scientists are encouraged to apply for OMRF Postdoc Travel Awards to support their attendance at meetings or workshops.
Applicants should have a Ph.D., M.D., or M.D./Ph.D. (or expect to receive a doctoral degree soon), possess excellent experimental and communication skills, and demonstrate solid training in cell biology, biochemistry, developmental biology, or mouse genetics with scientific publications. Previous research experience in metabolism is not required. In addition to competitive salaries and comprehensive benefits, the successful candidates will be provided with strong support for developing an independent research career after postdoctoral training.
Research Assistant / Senior Research Assistant
The laboratory of Dr. Pengchun Yu at the Oklahoma Medical Research Foundation (OMRF) is seeking a highly motivated individual to join our team. We are part of the Cardiovascular Biology Research Program at OMRF. Our research focuses on the interface between cellular metabolism and vascular biology. Specifically, we aim to elucidate the crosstalk between metabolic programs and angiogenic signaling events and to understand the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be employed, ranging from novel genetically-modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.
Responsibilities will include:
– Mammalian cell culture and virus-mediated genetic manipulation
– Biochemical and cell biology experiments to assess gene expression and function
– Mouse tissue dissection, immunohistochemistry, and confocal imaging
– Detailed documentation of experiments and results
– Participation in lab and departmental meetings
BS/BA/MS degree in one of the biological sciences and multiple years of professional, paid, relevant lab experience. Familiarity with basic lab techniques in molecular and cellular biology and biochemistry. Strong ability to coordinate day-to-day work, and follow protocols to complete a variety of detailed tasks and assignments. Ability to record detailed procedures and results. Familiarity with the internet and Microsoft Office. Excellent communication skills. Willingness to work collaboratively with others, as well as independently in areas of proficiency.
Preference will be given to candidates with extensive experience in cell biology, biochemistry, mouse genetics, and/or microscopy.
Job Summary/Basic Function
Assist with research activities directed toward understanding the roles of cellular metabolism in vascular development and disease. Basic duties will include working with laboratory mice, PCR genotyping, reagent preparation, ordering supplies, and general laboratory maintenance and organization. Additional responsibilities will include molecular and cellular biology and histology.
Bachelor’s degree typically in one of the biological sciences or equivalent years of professional, paid, relevant laboratory experience.
Basic computer skills including Internet software, order processing systems, and Microsoft Office software. Excellent oral and written communication skills required. Must be organized, take direction, keep meticulous records, and meet all deadlines. Professionalism and acceptance of diverse personalities and cultures are required.
Interest in genetics, molecular biology, developmental biology, or related fields. Previous experience with laboratory mice and PCR genotyping is a plus but not required.