Han F, Simeroth S, Zhu J, Gryniuk I, Pranay A, Chen W, Wang Y, Cai Y, Shen Z, Wang G, Griffin CT, Xia L, Yu P*.
Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis. Developmental Cell. 2025 Sep 8;60(17):2331-2347.e6. PubMed Central PMCID: PMC12353337.
Zhu J, Darko F, Han F, Simeroth S, Li L, Gu H, Yu P*. Untargeted metabolomic profiling reveals mTORC1-dependent
regulation of amino acid utilization in lymphatic endothelial cells. Vascular Pharmacology. 2026 Jun;163:107609. PubMed Central PMCID: PMC13157271.
Kim JD, Chaudhary S, Chen W, Astin J, Crosier PS, Yu P, Cooke JP, Pownall HJ, Bellen HJ, Le NT, Kiss DL, Wang G,
Rockson SG, Chen H, Fang L. APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving
caveolae-mediated inhibition of VEGFR3 signaling. Nature Communications. 2025 Oct 21;16(1):9286. PubMed Central PMCID:
PMC12540785.
Kondo Y, Jiang Y, Geng X, Song J, Simeroth S, McDaniel JM, Yu P, Srinivasan RS, Xia L. Site-1 protease-mediated
cholesterol metabolism is essential for lymphatic development in mice. JCI Insight. 2025 Oct 22;10(20) PubMed Central
PMCID: PMC12581667.
Simeroth S, Yu P*. The role of lymphatic endothelial cell metabolism in lymphangiogenesis and disease. Front Cardiovasc
Med. 2024;11:1392816. PubMed Central PMCID: PMC11119333.
Li P, Newhardt MF, Matsuzaki S, Eyster C, Pranay A, Peelor FF 3rd, Batushansky A, Kinter C, Subramani K, Subrahmanian S, Ahamed J, Yu P, Kinter M, Miller BF, Humphries KM. The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner. Geroscience, 2022 December, PMID: 36460774, PMCID: PMC9886736
Shi H, Shao B, Gao L, Venkatesan T, McDaniel JM, Zhou M, McGee S, Yu P, Ahamed J, Journeycake J, George JN, Xia L. Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease. Proc Natl Acad Sci U S A 119:e2207592119, 2022 August, PMID: 35969769, PMCID: PMC9407592
Song H, Zhu J, Li P, Han F, Fang L, Yu P*. Metabolic flexibility maintains proliferation and migration of FGFR signaling-deficient lymphatic endothelial cells. J Biol Chem:101149, 2021 August, PMID: 34473994, PMCID: PMC8498002
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, Smet FD, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, & Simons M (2017). FGF-dependent metabolic control of vascular development. Nature 545(7653):224-228. PMID: 28467822
Yu P, Alves TC, Kibbey RG & Simons M (2018). Metabolic Analysis of Lymphatic Endothelial Cells. Methods Mol Biol 1846:325-334.
Yu P, Wu G, Lee HW, & Simons M (2018). Endothelial Metabolic Control of Lymphangiogenesis. BioEssays 40(6):e1700245. PMID: 29750374
Yu P, Tung JK, & Simons M (2014). Lymphatic fate specification: an ERK-controlled transcriptional program. Microvascular Research 96:10-15. PMID: 25132472
Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, & Simons M (2012). Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation 126(22):2589-2600. PMID: 23091063
Yu P* & Du JL* (2011). Transient receptor potential canonical channels in angiogenesis and axon guidance. Cellular and Molecular Life Sciences 68(23):3815-3821. PMID: 21755360. (* Co-corresponding authors)
Yu P, Gu SY, Bu JW, & Du JL (2010). TRPC1 is essential for in vivo angiogenesis in zebrafish. Circulation Research 106(7):1221-1232. PMID: 20185799. (Highlighted in Faculty of 1000)
Huang C, Gu S, Yu P, Yu F, Feng C, Gao N, & Du J (2010). Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish. Developmental Biology 339(1):89-100. PMID: 20036229
Chen YM, Wang QJ, Hu HS, Yu P, Zhu J, Drewes G, Piwnica-Worms H, & Luo ZG (2006). Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc. Natl. Acad. Sci. USA 103(22):8534-8539. PMID: 16717194